Post-transcriptional regulation of the human liver/bone/kidney alkaline phosphatase gene
نویسندگان
چکیده
منابع مشابه
Transcriptional regulation of the human placental-like alkaline phosphatase gene and mechanisms involved in its induction by sodium butyrate.
The human alkaline phosphatases constitute a multigene family with at least four members. Placental-like alkaline phosphatase (PLAP) is of particular interest because it is frequently present in tumors, where it serves as a marker of malignant transformation. Moreover, its expression is highly inducible by differentiating agents such as sodium butyrate. In the present study we have examined the...
متن کاملAlkaline Phosphatase in Serum is a Marker of Human Toxocariasis
Background: The present study was carried out on the human population of Kashmir valley to evaluate the status of the biochemical parameters of infected population. Materials and Methods: Blood samples were collected from 514 individuals, 298 (57.97%) males and 216 (42.02%) females, 187 (36.38%) were found sero-positive for human toxocariasis. Results: Alkaline phosphatase level was found highe...
متن کاملPost-Transcriptional Regulation of Papillomavirus Gene Expression
Papillomavirus genomes are transcribed as one large complex transcription unit with multiple promoters, two poly(A) sites (early and late), and considerable alternative splicing. As a result, there are multiple opportunities for post-transcriptional regulation of papillomavirus gene expression. Although this area has not been as extensively studied as transcriptional regulation, there are a few...
متن کاملSequence and characterization of the human intestinal alkaline phosphatase gene.
At least four genes encode the human alkaline phosphatases (ALPs). The genes encoding three of these proteins (intestinal, placental, and placental-like ALPs), are linked on the long arm of chromosome 2, while the fourth gene (encoding liver/bone/kidney ALP) is located on chromosome 1. One of the linked genes, intestinal alkaline phosphatase, has been isolated on two overlapping phage clones an...
متن کاملStructure of the human liver/bone/kidney alkaline phosphatase gene.
In man, there are multiple forms of alkaline phosphatase encoded by at least three homologous genes: placental, intestinal, and liver/bone/kidney. This report describes the characterization of the human liver/bone/kidney alkaline phosphatase locus. The gene appears to exist as a single copy in the haploid genome and is comprised of 12 exons distributed over more than 50 kilobases. In liver, kid...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1991
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(20)64308-3